apalutamide will reduce the level or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicines which can be CYP3A4 substrates can result in lower exposure to those drugs.Even so, the waking mechanism of modafinil is still t